Empowering Innovation in Advanced Therapies

NANT XL PLUS System enables the perfect transition of your manual protocol into an automated process.

Automated subculturing from an initial 75/175 cm2 flask to a subsequent 1272/3180 cm2, 2 or 5-layer container. A competitive feature allowing to obtain large amounts of expanded cells even from small quantities of starting material or selecting cells population you’re interested in.

Easy to use, the NANT XL PLUS System supports a seamless transition from a manual manufacturing protocol to an automated process, customized to your specific requirements.

NANT XL PLUS System can automatically execute a predetermined sequence of instructions (cell culture protocol). Standardization of manufacturing processes and decrease in batch variability are essential to achieving the highest quality standards for cell therapy products.

Multiple NANT XL PLUS Systems enable manufacturing scale-out, thus significantly increasing the productivity and cost-effectiveness of cell therapy production.

Use of the NANT XL PLUS System requires minimal intervention by the operator.

Design and customize your own automated protocols, to the smallest detail.

NANT XL PLUS System is virtually able to perform endless automated protocols thanks to the customization of the cell-expansion process parameters: temperature and CO2 concentration in the cell culture compartment, position and movements of culture flasks, reagents transfer and microscopic imaging timeline, can be tailored to your manufacturing needs.

You can control the bioreactors' status and effortlessly record, track, and archive all protocol versions developed during the process development. At the end of the expansion phase, the NANT XL PLUS System automatically generates a cell culture report and provides all the recorded raw data.

With our built-in, fully automated and auto-focusing microscope system you can visually monitor your cell culture throughout the process. Even remotely.

Monitor and acquire pictures of your cells automatically, without accessing the cleanroom. Thought to save your time.

Our proprietary algorithm provides a fine estimate of cell confluency based on the images acquired. Medium change, subculturing, and cell harvesting can be triggered by this parameter according to protocol settings. Currently, this feature is optimized for Mesenchymal stem cells.

NANT XL PLUS System allows perfect real-time monitoring of the cell culture process, without accessing the cleanroom.

The NANT XL PLUS System enables remote and real-time monitoring of the status and the key process parameters of your ongoing cell culture.

Remote monitoring optimizes operators' time and activities, decreasing the cleanroom access, with a significant impact on the therapy cost reduction.Remote monitoring optimizes operators' time and activities, decreasing the cleanroom access, with a significant impact on the therapy cost reduction.

Thanks to its new industrial communication interface (ICI), NANT XL PLUS Bioreactor can be easily deployed to customers’ production facilities and integrated within their centralized industrial automation system. Thanks to the OPC-UA communication protocol, it can communicate with standard SCADA-based systems, as well as within pool orchestration layer (POL) architectures. Real-time remote monitoring of the most critical process parameters together with real-time collection of biological images and download of final process report are key features which help to keep high production quality standards.

Our NANT XL PLUS System increases productivity and reduces production costs, moving towards decentralized models of Advanced Therapies manufacturing.

NANT XL PLUS System supports the scale-out of cell therapy manufacturing, allowing an easy optimization of the cell expansion protocol with reduced cell culture volume, giving the opportunity to adjust the capacity of your facility according to the demand.

Cross-contamination is avoided thanks to our fully closed system, designed to ensure aseptic processing and cell culture expansion.

With its Quake detachment function, the NANT XL PLUS System offers advanced tray movements to facilitate the detachment of critical cell types in the culture process.

Our NANT XL PLUS System is designed for scale-out strategies, enabling the parallel operation of multiple units to meet increasing production demand and run multiple batches simultaneously without compromising process consistency.

Each system operates under the same controlled conditions, ensuring batch-to-batch consistency and facilitating process standardization across multiple production lines and sites.

By adding independent units instead of increasing single-batch volume, the NANT XL PLUS System allows flexible capacity expansion while minimizing risk and operational complexity. Multiple units can be efficiently monitored and controlled through the NANT Maestro OP platform, supporting decentralized manufacturing models.